The Prairie State College baseball program is a member of the National Junior College Athletic Association Region IV as well as the Illinois Skyway Collegiate Conference. The Pioneers have had several players earn all-region and all-conference status. Over the last three seasons, six Pioneers have moved on to continue their careers at the NCAA Division I level.
- MLB First-Year Player Draft Selections: Connor Ryan (Cincinnati Reds) (2017); Kevin Reiher (Atlanta Braves) (2014)
- 2014 NJCAA Region IV Sectional Champions
- 2013 NJCAA Region IV Sectional Champions
- 2013 Illinois Skyway Collegiate Conference Champions
- 40-Win Seasons: 2012